Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Top Medical Research Studies
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Most Useful Reviews
9
Well tolerated supplement
5 people found this helpful
I ordered Vitamin B6 alongside Magnesium. The tablets are small and easy to swallow, well tolerated by my body. It effectively enhances brain performance, as well as memory and mood.
9
Boosts brain function
3 people found this helpful
Vitamin B6 is essential! It enhances metabolism in brain tissues, acting as the main catalyst for amino acid metabolism and neurotransmitter synthesis in the nervous system. As a result, it improves brain performance, memory, and mood. Moreover, it regulates protein assimilation and supports hair growth, making it a common addition to cosmetic products.
9
Highly recommended
2 people found this helpful
Vitamin B6 improves metabolism in brain tissues, serving as the catalyst for amino acid exchange and the synthesis of neurotransmitters in the nervous system. It enhances brain performance, memory, and mood! I always reorder this vitamin as it truly helps. I trust this review has been beneficial to you.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Well tolerated supplement
5 people found this helpful
I ordered Vitamin B6 alongside Magnesium. The tablets are small and easy to swallow, well tolerated by my body. It effectively enhances brain performance, as well as memory and mood.
9
Boosts brain function
3 people found this helpful
Vitamin B6 is essential! It enhances metabolism in brain tissues, acting as the main catalyst for amino acid metabolism and neurotransmitter synthesis in the nervous system. As a result, it improves brain performance, memory, and mood. Moreover, it regulates protein assimilation and supports hair growth, making it a common addition to cosmetic products.
9
Highly recommended
2 people found this helpful
Vitamin B6 improves metabolism in brain tissues, serving as the catalyst for amino acid exchange and the synthesis of neurotransmitters in the nervous system. It enhances brain performance, memory, and mood! I always reorder this vitamin as it truly helps. I trust this review has been beneficial to you.
9
Vital for women
Fantastic! Vitamin B6 from Solgar is ideal for enhancing metabolism in brain tissues as the key catalyst for amino acid exchange and neurotransmitter synthesis. This vitamin significantly boosts brain performance, memory, and mood. For women, it's essential, alleviating depression, insomnia, and fatigue, plus it benefits hair and skin health!
9
Effective neurotransmitter support
Excellent! Vitamin B6 helps metabolism in brain tissues and is the main catalyst for amino acid metabolism and neurotransmitter synthesis. This vitamin remarkably boosts brain efficiency, memory, and mood.
Frequently Asked Questions
6
Improved energy levels
I took Vitamin B6 for better magnesium absorption and to enhance my memory and brain function. Solgar's quality is decent, and I noticed positive results with an average dosage of 25 mg over a two-month course. I've experienced better sleep, a calmer disposition, and increased energy. The small tablets are easy to swallow.
9
Well tolerated supplement
5 people found this helpful
I ordered Vitamin B6 alongside Magnesium. The tablets are small and easy to swallow, well tolerated by my body. It effectively enhances brain performance, as well as memory and mood.
7.5
Increases calmness
2 people found this helpful
Vitamin B6 has greatly assisted my husband. He took it for optimal brain function, and after a test, we found he became calmer and more resilient to stress. The quality is excellent, as is the packaging, and we appreciate the pleasant taste. We plan to continue using it, taking one capsule twice a day, with no complaints whatsoever. Highly recommend!
9
Supports heart and brain
My doctor recommended Vitamin B6 for heart and brain function. I opted for Solgar, a brand known for quality. After combining it with Vitamin B12, my heart's ECG came back clear, with no medical concerns. I’ve noticed improved clarity of thought. Recommend to others!
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
References
- Moosa NY, Azeem SA, Lodge JK, Cheung W, Ahmed SU. Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910428
- Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815
